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Genetic prion disease–related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM
Prion diseases are caused by the conformational conversion of prion protein (PrP). Forty-two different mutations were identified in human PrP, leading to genetic prion diseases with distinct clinical syndromes. Here, we report the cryo–electron microscopy structure of an amyloid fibril formed by ful...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442898/ https://www.ncbi.nlm.nih.gov/pubmed/34516876 http://dx.doi.org/10.1126/sciadv.abg9676 |