Genetic prion disease–related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM

Prion diseases are caused by the conformational conversion of prion protein (PrP). Forty-two different mutations were identified in human PrP, leading to genetic prion diseases with distinct clinical syndromes. Here, we report the cryo–electron microscopy structure of an amyloid fibril formed by ful...

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Detalles Bibliográficos
Autores principales: Wang, Li-Qiang, Zhao, Kun, Yuan, Han-Ye, Li, Xiang-Ning, Dang, Hai-Bin, Ma, Yeyang, Wang, Qiang, Wang, Chen, Sun, Yunpeng, Chen, Jie, Li, Dan, Zhang, Delin, Yin, Ping, Liu, Cong, Liang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442898/
https://www.ncbi.nlm.nih.gov/pubmed/34516876
http://dx.doi.org/10.1126/sciadv.abg9676

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