Mutation-induced DNMT1 cleavage drives neurodegenerative disease

Specific mutations within the replication foci targeting sequence (RFTS) domain of human DNMT1 are causative of two types of adult-onset neurodegenerative diseases, HSAN1E and ADCA-DN, but the underlying mechanisms are largely unknown. We generated Dnmt1-M1 and Dnmt1-M2 knock-in mouse models that ar...

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Detalles Bibliográficos
Autores principales: Wang, Wencai, Zhao, Xingsen, Shao, Yanjiao, Duan, Xiaoya, Wang, Yaling, Li, Jialun, Li, Jiwen, Li, Dali, Li, Xuekun, Wong, Jiemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442919/
https://www.ncbi.nlm.nih.gov/pubmed/34516921
http://dx.doi.org/10.1126/sciadv.abe8511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442919/
https://www.ncbi.nlm.nih.gov/pubmed/34516921
http://dx.doi.org/10.1126/sciadv.abe8511

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