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STAT1 maintains naïve CD8(+) T cell quiescence by suppressing the type I IFN-STAT4-mTORC1 signaling axis

Naïve CD8(+) T cell quiescence is maintained at a steady state. Although this state of quiescence involves various cell-intrinsic and cell-extrinsic regulators, the mechanisms underlying this regulation remain incompletely understood. Here, we found that signal transducer and activator of transcript...

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Detalles Bibliográficos
Autores principales: Kye, Yoon-Chul, Lee, Gil-Woo, Lee, Sung-Woo, Ju, Young-Jun, Kim, Hee-Ok, Yun, Cheol-Heui, Cho, Jae-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442933/
https://www.ncbi.nlm.nih.gov/pubmed/34516905
http://dx.doi.org/10.1126/sciadv.abg8764