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A thermodynamic model of protein structure evolution explains empirical amino acid substitution matrices
Proteins evolve under a myriad of biophysical selection pressures that collectively control the patterns of amino acid substitutions. These evolutionary pressures are sufficiently consistent over time and across protein families to produce substitution patterns, summarized in global amino acid subst...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442976/ https://www.ncbi.nlm.nih.gov/pubmed/34218472 http://dx.doi.org/10.1002/pro.4155 |