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A thermodynamic model of protein structure evolution explains empirical amino acid substitution matrices

Proteins evolve under a myriad of biophysical selection pressures that collectively control the patterns of amino acid substitutions. These evolutionary pressures are sufficiently consistent over time and across protein families to produce substitution patterns, summarized in global amino acid subst...

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Detalles Bibliográficos
Autores principales: Norn, Christoffer, André, Ingemar, Theobald, Douglas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442976/
https://www.ncbi.nlm.nih.gov/pubmed/34218472
http://dx.doi.org/10.1002/pro.4155