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Differential contribution to gene expression prediction of histone modifications at enhancers or promoters

The ChIP-seq signal of histone modifications at promoters is a good predictor of gene expression in different cellular contexts, but whether this is also true at enhancers is not clear. To address this issue, we develop quantitative models to characterize the relationship of gene expression with his...

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Detalles Bibliográficos
Autores principales: González-Ramírez, Mar, Ballaré, Cecilia, Mugianesi, Francesca, Beringer, Malte, Santanach, Alexandra, Blanco, Enrique, Di Croce, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443064/
https://www.ncbi.nlm.nih.gov/pubmed/34473698
http://dx.doi.org/10.1371/journal.pcbi.1009368