Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

The NLRP3 inflammasome is activated by a wide range of stimuli and drives diverse inflammatory diseases. The decrease of intracellular K(+) concentration is a minimal upstream signal to most of the NLRP3 activation models. Here, we found that cellular K(+) efflux induces a stable structural change i...

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Detalles Bibliográficos
Autores principales: Tapia-Abellán, Ana, Angosto-Bazarra, Diego, Alarcón-Vila, Cristina, Baños, María C., Hafner-Bratkovič, Iva, Oliva, Baldomero, Pelegrín, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443177/
https://www.ncbi.nlm.nih.gov/pubmed/34524838
http://dx.doi.org/10.1126/sciadv.abf4468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443177/
https://www.ncbi.nlm.nih.gov/pubmed/34524838
http://dx.doi.org/10.1126/sciadv.abf4468

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