Versatile cell-based assay for measuring DNA alkylation damage and its repair

DNA alkylation damage induced by environmental carcinogens, chemotherapy drugs, or endogenous metabolites plays a central role in mutagenesis, carcinogenesis, and cancer therapy. Base excision repair (BER) is a conserved, front line DNA repair pathway that removes alkylation damage from DNA. The cap...

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Detalles Bibliográficos
Autores principales: Li, Yong, Mao, Peng, Basenko, Evelina Y., Lewis, Zachary, Smerdon, Michael J., Czaja, Wioletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443546/
https://www.ncbi.nlm.nih.gov/pubmed/34526526
http://dx.doi.org/10.1038/s41598-021-97523-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443546/
https://www.ncbi.nlm.nih.gov/pubmed/34526526
http://dx.doi.org/10.1038/s41598-021-97523-w

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