C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates

Sensitized kidney transplant recipients experience high rates of antibody-mediated rejection due to the presence of donor-specific antibodies and immunologic memory. Here we show that transient peri-transplant treatment with the central complement component C3 inhibitor Cp40 significantly prolongs m...

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Detalles Bibliográficos
Autores principales: Schmitz, Robin, Fitch, Zachary W., Schroder, Paul M., Choi, Ashley Y., Manook, Miriam, Yoon, Janghoon, Song, Mingqing, Yi, John S., Khandelwal, Sanjay, Arepally, Gowthami M., Farris, Alton B., Reis, Edimara S., Lambris, John D., Kwun, Jean, Knechtle, Stuart J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443599/
https://www.ncbi.nlm.nih.gov/pubmed/34526511
http://dx.doi.org/10.1038/s41467-021-25745-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443599/
https://www.ncbi.nlm.nih.gov/pubmed/34526511
http://dx.doi.org/10.1038/s41467-021-25745-7

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