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C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates
Sensitized kidney transplant recipients experience high rates of antibody-mediated rejection due to the presence of donor-specific antibodies and immunologic memory. Here we show that transient peri-transplant treatment with the central complement component C3 inhibitor Cp40 significantly prolongs m...
Autores principales: | Schmitz, Robin, Fitch, Zachary W., Schroder, Paul M., Choi, Ashley Y., Manook, Miriam, Yoon, Janghoon, Song, Mingqing, Yi, John S., Khandelwal, Sanjay, Arepally, Gowthami M., Farris, Alton B., Reis, Edimara S., Lambris, John D., Kwun, Jean, Knechtle, Stuart J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443599/ https://www.ncbi.nlm.nih.gov/pubmed/34526511 http://dx.doi.org/10.1038/s41467-021-25745-7 |
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