K(Ca) channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549)

Non-small cell lung cancer (NSCLC) has a poor prognosis with a 5 year survival rate of only ~ 10%. Important driver mutations underlying NSCLC affect the epidermal growth factor receptor (EGFR) causing the constitutive activation of its tyrosine kinase domain. There are efficient EGFR tyrosine kinas...

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Detalles Bibliográficos
Autores principales: Glaser, Felix, Hundehege, Petra, Bulk, Etmar, Todesca, Luca Matteo, Schimmelpfennig, Sandra, Nass, Elke, Budde, Thomas, Meuth, Sven G., Schwab, Albrecht
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443639/
https://www.ncbi.nlm.nih.gov/pubmed/34526525
http://dx.doi.org/10.1038/s41598-021-97406-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443639/
https://www.ncbi.nlm.nih.gov/pubmed/34526525
http://dx.doi.org/10.1038/s41598-021-97406-0

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