USP11 controls R-loops by regulating senataxin proteostasis

R-loops are by-products of transcription that must be tightly regulated to maintain genomic stability and gene expression. Here, we describe a mechanism for the regulation of the R-loop-specific helicase, senataxin (SETX), and identify the ubiquitin specific peptidase 11 (USP11) as an R-loop regulat...

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Detalles Bibliográficos
Autores principales: Jurga, Mateusz, Abugable, Arwa A., Goldman, Alastair S. H., El-Khamisy, Sherif F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443744/
https://www.ncbi.nlm.nih.gov/pubmed/34526504
http://dx.doi.org/10.1038/s41467-021-25459-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443744/
https://www.ncbi.nlm.nih.gov/pubmed/34526504
http://dx.doi.org/10.1038/s41467-021-25459-w

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