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Activation of β3-adrenoceptor increases the number of readily releasable glutamatergic vesicle via activating Ca(2+)/calmodulin/MLCK/myosin II pathway in the prefrontal cortex of juvenile rats

It is well known that β3-adrenoceptor (β3-AR) in many brain structures including prefrontal cortex (PFC) is involved in stress-related behavioral changes. SR58611A, a brain-penetrant β3-AR subtypes agonist, is revealed to exhibit anxiolytic- and antidepressant-like effects. Whereas activation of β3-...

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Detalles Bibliográficos
Autores principales: Wang, Xing, Sun, Xuan, Zhou, Hou-Cheng, Luo, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443757/
https://www.ncbi.nlm.nih.gov/pubmed/34526598
http://dx.doi.org/10.1038/s41598-021-97769-4