Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data

A physiologically based pharmacokinetic model for Di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the biokinetics in humans after single oral doses. The model was parameterized with in vitro and in silico derived parameters and uncertainty and sensitivity analysis was used during the...

Descripción completa

Detalles Bibliográficos
Autores principales: McNally, Kevin, Sams, Craig, Hogg, Alex, Lumen, Annie, Loizou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443793/
https://www.ncbi.nlm.nih.gov/pubmed/34539393
http://dx.doi.org/10.3389/fphar.2021.692442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443793/
https://www.ncbi.nlm.nih.gov/pubmed/34539393
http://dx.doi.org/10.3389/fphar.2021.692442

Ejemplares similares