The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling

BACKGROUND: Cell-to-cell heterogeneity is an inherent feature of multicellular organisms and is central in all physiological and pathophysiological processes including cellular signal transduction. The cytokine IL-6 is an essential mediator of pro- and anti-inflammatory processes. Dysregulated IL-6-...

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Detalles Bibliográficos
Autores principales: Fiebelkow, Jessica, Guendel, André, Guendel, Beate, Mehwald, Nora, Jetka, Tomasz, Komorowski, Michal, Waldherr, Steffen, Schaper, Fred, Dittrich, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444181/
https://www.ncbi.nlm.nih.gov/pubmed/34530865
http://dx.doi.org/10.1186/s12964-021-00770-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444181/
https://www.ncbi.nlm.nih.gov/pubmed/34530865
http://dx.doi.org/10.1186/s12964-021-00770-7

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