Pd-Catalyzed Direct Modification of an Anti-Alzheimer’s Disease Drug: Synthesis and Biological Evaluation of α-Aryl Donepezil Analogues

[Image: see text] Palladium/BuAd(2)P efficiently catalyzed the direct α-arylation of ketone in the anti-Alzheimer’s disease drug donepezil, leading to 15 aryldonepezil analogues exhibiting high selective inhibition of acetylcholinesterase (AChE). The cell-based assays revealed that the 3-methylpridi...

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Detalles Bibliográficos
Autores principales: Wan, Lin-Xi, Miao, Shi-Xing, He, Zhen-Xiang, Li, Xiaohuan, Zhou, Xian-Li, Gao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444293/
https://www.ncbi.nlm.nih.gov/pubmed/34549134
http://dx.doi.org/10.1021/acsomega.1c03103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444293/
https://www.ncbi.nlm.nih.gov/pubmed/34549134
http://dx.doi.org/10.1021/acsomega.1c03103

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