Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence

Spinocerebellar ataxia type 2 is a polyglutamine (polyQ) disease associated with an expanded polyQ domain within the protein product of the ATXN2 gene. Interestingly, polyQ repeat expansions in ATXN2 are also associated with amyotrophic lateral sclerosis (ALS) and parkinsonism depending upon the len...

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Detalles Bibliográficos
Autores principales: McGurk, Leeanne, Rifai, Olivia M, Shcherbakova, Oksana, Perlegos, Alexandra E, Byrns, China N, Carranza, Faith R, Zhou, Henry W, Kim, Hyung-Jun, Zhu, Yongqing, Bonini, Nancy M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444453/
https://www.ncbi.nlm.nih.gov/pubmed/34077532
http://dx.doi.org/10.1093/hmg/ddab148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444453/
https://www.ncbi.nlm.nih.gov/pubmed/34077532
http://dx.doi.org/10.1093/hmg/ddab148

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