Cargando…

Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence

Spinocerebellar ataxia type 2 is a polyglutamine (polyQ) disease associated with an expanded polyQ domain within the protein product of the ATXN2 gene. Interestingly, polyQ repeat expansions in ATXN2 are also associated with amyotrophic lateral sclerosis (ALS) and parkinsonism depending upon the len...

Descripción completa

Detalles Bibliográficos
Autores principales:	McGurk, Leeanne, Rifai, Olivia M, Shcherbakova, Oksana, Perlegos, Alexandra E, Byrns, China N, Carranza, Faith R, Zhou, Henry W, Kim, Hyung-Jun, Zhu, Yongqing, Bonini, Nancy M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444453/ https://www.ncbi.nlm.nih.gov/pubmed/34077532 http://dx.doi.org/10.1093/hmg/ddab148

Ejemplares similares

TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2
por: McGurk, Leeanne, et al.
Publicado: (2020)

Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila
por: McGurk, Leeanne, et al.
Publicado: (2012)

Inhibiting Expression of Mutant Huntingtin and Ataxin-3 by Targeting Expanded CAG Repeat RNAs
por: Hu, Jiaxin, et al.
Publicado: (2009)

m(1)A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration
por: Sun, Yuxiang, et al.
Publicado: (2023)

Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation
por: McGurk, Leeanne, et al.
Publicado: (2018)

Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila
por: Shieh, Shin-Yi, et al.
Publicado: (2011)

Genome-Wide Screen for Modifiers of Ataxin-3 Neurodegeneration in Drosophila
por: Bilen, Julide, et al.
Publicado: (2007)

Three-Dimensional Imaging of Drosophila melanogaster
por: McGurk, Leeanne, et al.
Publicado: (2007)

Ensheathing glia promote increased lifespan and healthy brain aging
por: Sheng, Lihong, et al.
Publicado: (2023)

The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster
por: McGurk, Leeanne, et al.
Publicado: (2008)

Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3
por: Jung, Joonil, et al.
Publicado: (2009)

In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats
por: Figura, Grzegorz, et al.
Publicado: (2015)

dAtaxin-2 Mediates Expanded Ataxin-1-Induced Neurodegeneration in a Drosophila Model of SCA1
por: Al-Ramahi, Ismael, et al.
Publicado: (2007)

CAG repeats mimic CUG repeats in the misregulation of alternative splicing
por: Mykowska, Agnieszka, et al.
Publicado: (2011)

Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing
por: McIntosh, Craig S., et al.
Publicado: (2019)

Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy
por: Khan, Anzer, et al.
Publicado: (2020)

Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila
por: del Castillo, Urko, et al.
Publicado: (2021)

Mettl3-dependent m(6)A modification attenuates the brain stress response in Drosophila
por: Perlegos, Alexandra E., et al.
Publicado: (2022)

Ecological factors in human development /
por: McGurk, Harry
Publicado: (1977)

FOX-2 Dependent Splicing of Ataxin-2 Transcript Is Affected by Ataxin-1 Overexpression
por: Welzel, Franziska, et al.
Publicado: (2012)

CAG·CTG repeat instability in cultured human astrocytes
por: Farrell, Brian T., et al.
Publicado: (2006)

Intermediate CAG Repeats in Huntington's Disease: Analysis of COHORT
por: Ha, Ainhi D., et al.
Publicado: (2012)

Mechanisms of RNA-induced toxicity in CAG repeat disorders
por: Nalavade, R, et al.
Publicado: (2013)

Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action
por: Tirabassi, Giacomo, et al.
Publicado: (2015)

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases
por: Zhang, Nan, et al.
Publicado: (2021)

Development of Fluorescent Turn-On Probes for CAG-RNA Repeats
por: Lau, Matthew Ho Yan, et al.
Publicado: (2022)

Therapeutic modulation of eIF2α-phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
por: Kim, Hyung-Jun, et al.
Publicado: (2013)

Approaches to Sequence the HTT CAG Repeat Expansion and Quantify Repeat Length Variation
por: Ciosi, Marc, et al.
Publicado: (2021)

In vivo zebrafish morphogenesis shows Cyp26b1 promotes tendon condensation and musculoskeletal patterning in the embryonic jaw
por: McGurk, Patrick D., et al.
Publicado: (2017)

Long Tract of Untranslated CAG Repeats Is Deleterious in Transgenic Mice
por: Hsu, Ren-Jun, et al.
Publicado: (2011)

CAG Repeat Number in the Androgen Receptor Gene and Prostate Cancer
por: Madjunkova, S, et al.
Publicado: (2012)

The central role of DNA damage and repair in CAG repeat diseases
por: Massey, Thomas H., et al.
Publicado: (2018)

Assessing average somatic CAG repeat instability at the protein level
por: Aviolat, Hubert, et al.
Publicado: (2019)

The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference
por: Murmann, Andrea E., et al.
Publicado: (2022)

Model Organisms Reveal Insight into Human Neurodegenerative Disease: Ataxin-2 Intermediate-Length Polyglutamine Expansions Are a Risk Factor for ALS
por: Bonini, Nancy M., et al.
Publicado: (2011)

Nucleocytoplasmic Shuttling Activity of Ataxin-3
por: Macedo-Ribeiro, Sandra, et al.
Publicado: (2009)

Patterns of piRNA Regulation in Drosophila Revealed through Transposable Element Clade Inference
por: Said, Iskander, et al.
Publicado: (2021)

Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis
por: Tian, Jie, et al.
Publicado: (2015)

Universal RNAi Triggers for the Specific Inhibition of Mutant Huntingtin, Atrophin-1, Ataxin-3, and Ataxin-7 Expression
por: Kotowska-Zimmer, Anna, et al.
Publicado: (2019)

Management of Salivary Gland Tumours: United Kingdom National Multidisciplinary Guidelines
por: Sood, S, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kckmojajk5v5epkugkjgmqgrvn