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Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring

Abnormally elevated expression of the imprinted PHLDA2 gene has been reported in the placenta of human babies that are growth restricted in utero in several studies. We previously modelled this gene alteration in mice and found that just 2-fold increased expression of Phlda2 resulted in placental en...

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Detalles Bibliográficos
Autores principales: Harrison, David J, Creeth, Hugo D J, Tyson, Hannah R, Boque-Sastre, Raquel, Hunter, Susan, Dwyer, Dominic M, Isles, Anthony R, John, Rosalind M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444454/
https://www.ncbi.nlm.nih.gov/pubmed/34100083
http://dx.doi.org/10.1093/hmg/ddab154