Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB–Mediated Production of CXCL1

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with few effective therapeutic options. PDAC is characterized by an extensive fibroinflammatory stroma that includes abundant infiltrating immune cells. Tumor-associated macrophages (TAM) are prevalent within the stroma and are key drive...

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Detalles Bibliográficos
Autores principales: Kemp, Samantha B., Carpenter, Eileen S., Steele, Nina G., Donahue, Katelyn L., Nwosu, Zeribe C., Pacheco, Amanda, Velez-Delgado, Ashley, Menjivar, Rosa E., Lima, Fatima, The, Stephanie, Espinoza, Carlos E., Brown, Kristee, Long, Daniel, Lyssiotis, Costas A., Rao, Arvind, Zhang, Yaqing, Pasca di Magliano, Marina, Crawford, Howard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Tumor Biology and Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445065/
https://www.ncbi.nlm.nih.gov/pubmed/34049975
http://dx.doi.org/10.1158/0008-5472.CAN-20-3929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445065/
https://www.ncbi.nlm.nih.gov/pubmed/34049975
http://dx.doi.org/10.1158/0008-5472.CAN-20-3929

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