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Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy

Protein post-translational modifications are involved in essentially all aspects of cellular signaling. Their dynamic nature and the difficulties in installing them using enzymatic approaches limits their direct study in human cells. Reported herein is the first synthesis, delivery and cellular stud...

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Detalles Bibliográficos
Autores principales: Mann, Guy, Satish, Gandhesiri, Sulkshane, Prasad, Mandal, Shaswati, Glickman, Michael H., Brik, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445162/
https://www.ncbi.nlm.nih.gov/pubmed/34528945
http://dx.doi.org/10.1039/d1cc04045f