Genomic stability at the coding regions of the multidrug transporter gene ABCB1: insights into the development of alternative drug resistance mechanisms in human leukemia cells

Aim: Despite considerable efforts to reverse clinical multidrug resistance (MDR), targeting the predominant multidrug transporter ABCB1/P-glycoprotein (P-gp) using small molecule inhibitors has been unsuccessful, possibly due to the emergence of alternative drug resistance mechanisms. However, the n...

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Detalles Bibliográficos
Autores principales: Chen, Kevin G., Duran, George E., Mogul, Mark J., Wang, Yan C., Ross, Kevin L., Jaffrézou, Jean-Pierre, Huff, Lyn M., Johnson, Kory R., Fojo, Tito, Lacayo, Norman J., Sikic, Branimir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445225/
https://www.ncbi.nlm.nih.gov/pubmed/34541464
http://dx.doi.org/10.20517/cdr.2020.51

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445225/
https://www.ncbi.nlm.nih.gov/pubmed/34541464
http://dx.doi.org/10.20517/cdr.2020.51

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