A comprehensive integrated post-GWAS analysis of Type 1 diabetes reveals enhancer-based immune dysregulation

Type 1 diabetes (T1D) is an organ-specific autoimmune disease, whereby immune cell-mediated killing leads to loss of the insulin-producing β cells in the pancreas. Genome-wide association studies (GWAS) have identified over 200 genetic variants associated with risk for T1D. The majority of the GWAS...

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Detalles Bibliográficos
Autores principales: Kim, Seung-Soo, Hudgins, Adam D., Yang, Jiping, Zhu, Yizhou, Tu, Zhidong, Rosenfeld, Michael G., DiLorenzo, Teresa P., Suh, Yousin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445446/
https://www.ncbi.nlm.nih.gov/pubmed/34529725
http://dx.doi.org/10.1371/journal.pone.0257265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445446/
https://www.ncbi.nlm.nih.gov/pubmed/34529725
http://dx.doi.org/10.1371/journal.pone.0257265

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