Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical

BACKGROUND: Excessive plasma histamine concentrations cause symptoms in mast cell activation syndrome, mastocytosis, or anaphylaxis. Anti-histamines are often insufficiently efficacious. Human diamine oxidase (hDAO) can rapidly degrade histamine and therefore represents a promising new treatment str...

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Detalles Bibliográficos
Autores principales: Gludovacz, Elisabeth, Schuetzenberger, Kornelia, Resch, Marlene, Tillmann, Katharina, Petroczi, Karin, Schosserer, Markus, Vondra, Sigrid, Vakal, Serhii, Klanert, Gerald, Pollheimer, Jürgen, Salminen, Tiina A, Jilma, Bernd, Borth, Nicole, Boehm, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445614/
https://www.ncbi.nlm.nih.gov/pubmed/34477104
http://dx.doi.org/10.7554/eLife.68542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445614/
https://www.ncbi.nlm.nih.gov/pubmed/34477104
http://dx.doi.org/10.7554/eLife.68542

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