Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease

We have discovered a family of synthetic oxazole-based macrocycles to be active against SARS-CoV-2. The synthesis, pharmacological properties, and docking studies of the compounds are reported in this study. The structure of the new macrocycles was confirmed by NMR spectroscopy and mass spectrometry...

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Detalles Bibliográficos
Autores principales: Al-Wahaibi, Lamya H., Mostafa, Ahmed, Mostafa, Yaser A., Abou-Ghadir, Ola F., Abdelazeem, Ahmed H., Gouda, Ahmed M., Kutkat, Omnia, Abo Shama, Noura M., Shehata, Mahmoud, Gomaa, Hesham A.M., Abdelrahman, Mostafa H., Mohamed, Fatma A.M., Gu, Xuyuan, Ali, Mohamed A., Trembleau, Laurent, Youssif, Bahaa G.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445767/
https://www.ncbi.nlm.nih.gov/pubmed/34555629
http://dx.doi.org/10.1016/j.bioorg.2021.105363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445767/
https://www.ncbi.nlm.nih.gov/pubmed/34555629
http://dx.doi.org/10.1016/j.bioorg.2021.105363

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