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Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles

Treatment and prevention of human immunodeficiency virus type one (HIV-1) infection was transformed through widespread use of antiretroviral therapy (ART). However, ART has limitations in requiring life-long daily adherence. Such limitations have led to the creation of long-acting (LA) ART. While nu...

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Detalles Bibliográficos
Autores principales: Cobb, Denise A., Smith, Nathan, Deodhar, Suyash, Bade, Aditya N., Gautam, Nagsen, Shetty, Bhagya Laxmi Dyavar, McMillan, JoEllyn, Alnouti, Yazen, Cohen, Samuel M., Gendelman, Howard E., Edagwa, Benson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445934/
https://www.ncbi.nlm.nih.gov/pubmed/34531390
http://dx.doi.org/10.1038/s41467-021-25690-5