A forward genetic screen identifies modifiers of rocaglate responsiveness

Rocaglates are a class of eukaryotic translation initiation inhibitors that are being explored as chemotherapeutic agents. They function by targeting eukaryotic initiation factor (eIF) 4A, an RNA helicase critical for recruitment of the 40S ribosome (and associated factors) to mRNA templates. Rocagl...

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Detalles Bibliográficos
Autores principales: Shen, Leo, Pugsley, Lauren, Cencic, Regina, Wang, HanChen, Robert, Francis, Naineni, Sai Kiran, Sahni, Ananya, Morin, Geneviève, Zhang, Wenhan, Nijnik, Anastasia, Porco, John A., Langlais, David, Huang, Sidong, Pelletier, Jerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445955/
https://www.ncbi.nlm.nih.gov/pubmed/34531456
http://dx.doi.org/10.1038/s41598-021-97765-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445955/
https://www.ncbi.nlm.nih.gov/pubmed/34531456
http://dx.doi.org/10.1038/s41598-021-97765-8

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