Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5

Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward flow, which is sensed by cells at the left LRO margin. Ciliary activity of the calcium channel Pkd2 is crucial for flow sensing. How this flow signal is further processed and relayed to the laterality-determi...

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Detalles Bibliográficos
Autores principales: Maerker, Markus, Getwan, Maike, Dowdle, Megan E., McSheene, Jason C., Gonzalez, Vanessa, Pelliccia, José L., Hamilton, Danielle S., Yartseva, Valeria, Vejnar, Charles, Tingler, Melanie, Minegishi, Katsura, Vick, Philipp, Giraldez, Antonio J., Hamada, Hiroshi, Burdine, Rebecca D., Sheets, Michael D., Blum, Martin, Schweickert, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446035/
https://www.ncbi.nlm.nih.gov/pubmed/34531379
http://dx.doi.org/10.1038/s41467-021-25464-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446035/
https://www.ncbi.nlm.nih.gov/pubmed/34531379
http://dx.doi.org/10.1038/s41467-021-25464-z

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