Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia

T-cell dysfunction is a hallmark of B-cell Chronic Lymphocytic Leukemia (CLL), where CLL cells downregulate T-cell responses through regulatory molecules including programmed death ligand-1 (PD-L1) and Interleukin-10 (IL-10). Immune checkpoint blockade (ICB) aims to restore T-cell function by preven...

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Detalles Bibliográficos
Autores principales: Rivas, J.R., Liu, Y., Alhakeem, S.S., Eckenrode, J.M., Marti, F., Collard, J.P., Zhang, Y., Shaaban, K.A., Muthusamy, N., Hildebrandt, G.C., Fleischman, R.A., Chen, L., Thorson, J.S., Leggas, M., Bondada, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446094/
https://www.ncbi.nlm.nih.gov/pubmed/33731852
http://dx.doi.org/10.1038/s41375-021-01217-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446094/
https://www.ncbi.nlm.nih.gov/pubmed/33731852
http://dx.doi.org/10.1038/s41375-021-01217-1

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