Gene Therapy Using Adeno‐Associated Virus Serotype 8 Encoding TNAP‐D(10) Improves the Skeletal and Dentoalveolar Phenotypes in Alpl (−/−) Mice

Hypophosphatasia (HPP) is caused by loss‐of‐function mutations in the ALPL gene that encodes tissue‐nonspecific alkaline phosphatase (TNAP), whose deficiency results in the accumulation of extracellular inorganic pyrophosphate (PP(i)), a potent mineralization inhibitor. Skeletal and dental hypominer...

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Detalles Bibliográficos
Autores principales: Kinoshita, Yuka, Mohamed, Fatma F, Amadeu de Oliveira, Flavia, Narisawa, Sonoko, Miyake, Koichi, Foster, Brian L, Millán, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446309/
https://www.ncbi.nlm.nih.gov/pubmed/34076297
http://dx.doi.org/10.1002/jbmr.4382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446309/
https://www.ncbi.nlm.nih.gov/pubmed/34076297
http://dx.doi.org/10.1002/jbmr.4382

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