Cargando…
Integrated pan‐cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance
INTRODUCTION: The AURKA gene encodes a protein kinase involved in cell cycle regulation and plays an oncogenic role in many cancers. The main objective of this study is to analyze AURKA expression in 13 common cancers and its role in prognostic and drug resistance. METHOD: Using the cancer genome at...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446408/ https://www.ncbi.nlm.nih.gov/pubmed/34337875 http://dx.doi.org/10.1002/cam4.4161 |
_version_ | 1784568865569636352 |
---|---|
author | Miralaei, Noushin Majd, Ahmad Ghaedi, Kamran Peymani, Maryam Safaei, Masoomeh |
author_facet | Miralaei, Noushin Majd, Ahmad Ghaedi, Kamran Peymani, Maryam Safaei, Masoomeh |
author_sort | Miralaei, Noushin |
collection | PubMed |
description | INTRODUCTION: The AURKA gene encodes a protein kinase involved in cell cycle regulation and plays an oncogenic role in many cancers. The main objective of this study is to analyze AURKA expression in 13 common cancers and its role in prognostic and drug resistance. METHOD: Using the cancer genome atlas (TCGA) as well as CCLE and GDSC data, the level of AURKA gene expression and its role in prognosis and its association with drug resistance were evaluated, respectively. In addition, the expression level of AURKA was assessed in colorectal cancer (CRC) and gastric cancer (GC) samples. Besides, using Gene Expression Omnibus (GEO) data, drugs that could affect the expression level of this gene were also identified. RESULTS: The results indicated that the expression level of AURKA gene in 13 common cancers increased significantly compared to normal samples or it survived poorly (HR >1, p < 0.01) in lung, prostate, kidney, bladder, and uterine cancers. Also, the gene expression data showed increased expression in CRC and GC samples compared to normal ones. The level of AURKA was significantly associated with the resistance to SB 505124, NU‐7441, and irinotecan drugs (p < 0.01). Eventually, GEO data showed that JQ1, actinomycin D1, and camptothecin could reduce the expression of AURKA gene in different cancer cell lines (logFC < 1, p < 0.01). CONCLUSION: Increased expression of AURKA is observed in prevalent cancers and associated with poor prognostic and the development of drug resistance. In addition, some chemotherapy drugs can reduce the expression of this gene. |
format | Online Article Text |
id | pubmed-8446408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84464082021-09-22 Integrated pan‐cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance Miralaei, Noushin Majd, Ahmad Ghaedi, Kamran Peymani, Maryam Safaei, Masoomeh Cancer Med Cancer Biology INTRODUCTION: The AURKA gene encodes a protein kinase involved in cell cycle regulation and plays an oncogenic role in many cancers. The main objective of this study is to analyze AURKA expression in 13 common cancers and its role in prognostic and drug resistance. METHOD: Using the cancer genome atlas (TCGA) as well as CCLE and GDSC data, the level of AURKA gene expression and its role in prognosis and its association with drug resistance were evaluated, respectively. In addition, the expression level of AURKA was assessed in colorectal cancer (CRC) and gastric cancer (GC) samples. Besides, using Gene Expression Omnibus (GEO) data, drugs that could affect the expression level of this gene were also identified. RESULTS: The results indicated that the expression level of AURKA gene in 13 common cancers increased significantly compared to normal samples or it survived poorly (HR >1, p < 0.01) in lung, prostate, kidney, bladder, and uterine cancers. Also, the gene expression data showed increased expression in CRC and GC samples compared to normal ones. The level of AURKA was significantly associated with the resistance to SB 505124, NU‐7441, and irinotecan drugs (p < 0.01). Eventually, GEO data showed that JQ1, actinomycin D1, and camptothecin could reduce the expression of AURKA gene in different cancer cell lines (logFC < 1, p < 0.01). CONCLUSION: Increased expression of AURKA is observed in prevalent cancers and associated with poor prognostic and the development of drug resistance. In addition, some chemotherapy drugs can reduce the expression of this gene. John Wiley and Sons Inc. 2021-08-01 /pmc/articles/PMC8446408/ /pubmed/34337875 http://dx.doi.org/10.1002/cam4.4161 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Biology Miralaei, Noushin Majd, Ahmad Ghaedi, Kamran Peymani, Maryam Safaei, Masoomeh Integrated pan‐cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance |
title | Integrated pan‐cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance |
title_full | Integrated pan‐cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance |
title_fullStr | Integrated pan‐cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance |
title_full_unstemmed | Integrated pan‐cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance |
title_short | Integrated pan‐cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance |
title_sort | integrated pan‐cancer of aurka expression and drug sensitivity analysis reveals increased expression of aurka is responsible for drug resistance |
topic | Cancer Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446408/ https://www.ncbi.nlm.nih.gov/pubmed/34337875 http://dx.doi.org/10.1002/cam4.4161 |
work_keys_str_mv | AT miralaeinoushin integratedpancancerofaurkaexpressionanddrugsensitivityanalysisrevealsincreasedexpressionofaurkaisresponsiblefordrugresistance AT majdahmad integratedpancancerofaurkaexpressionanddrugsensitivityanalysisrevealsincreasedexpressionofaurkaisresponsiblefordrugresistance AT ghaedikamran integratedpancancerofaurkaexpressionanddrugsensitivityanalysisrevealsincreasedexpressionofaurkaisresponsiblefordrugresistance AT peymanimaryam integratedpancancerofaurkaexpressionanddrugsensitivityanalysisrevealsincreasedexpressionofaurkaisresponsiblefordrugresistance AT safaeimasoomeh integratedpancancerofaurkaexpressionanddrugsensitivityanalysisrevealsincreasedexpressionofaurkaisresponsiblefordrugresistance |