Bridging the Bridging Imidazolate in the Bimetallic Center of the Cu/Zn SOD1 and ALS

Metallation status of human Cu/Zn superoxide dismutase 1 (SOD1) plays a pivotal role in the pathogenesis of amyotrophic lateral sclerosis (ALS). All of the amino acids found in the bimetallic center have been associated with ALS except for two positions. H63 which forms the bridging imidazolate ion...

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Detalles Bibliográficos
Autores principales: Timucin, Ahmet Can, Cinaroglu, Suleyman Selim, Sezerman, Osman Ugur, Timucin, Emel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446448/
https://www.ncbi.nlm.nih.gov/pubmed/34540798
http://dx.doi.org/10.3389/fchem.2021.716438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446448/
https://www.ncbi.nlm.nih.gov/pubmed/34540798
http://dx.doi.org/10.3389/fchem.2021.716438

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