Autosomal Recessive Cutis Laxa 1C Mutations Disrupt the Structure and Interactions of Latent TGFβ Binding Protein-4

Latent TGFβ binding protein-4 (LTBP4) is a multi-domain glycoprotein, essential for regulating the extracellular bioavailability of TGFβ and assembly of elastic fibre proteins, fibrillin-1 and tropoelastin. LTBP4 mutations are linked to autosomal recessive cutis laxa type 1C (ARCL1C), a rare congeni...

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Detalles Bibliográficos
Autores principales: Alanazi, Yasmene F., Lockhart-Cairns, Michael P., Cain, Stuart A., Jowitt, Thomas A., Weiss, Anthony S., Baldock, Clair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446450/
https://www.ncbi.nlm.nih.gov/pubmed/34539739
http://dx.doi.org/10.3389/fgene.2021.706662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446450/
https://www.ncbi.nlm.nih.gov/pubmed/34539739
http://dx.doi.org/10.3389/fgene.2021.706662

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