Phosphodiesterase-4D Knockdown in the Prefrontal Cortex Alleviates Memory Deficits and Synaptic Failure in Mouse Model of Alzheimer’s Disease

Phosphodiesterase 4 (PDE4)-dependent cAMP signaling plays a crucial role in cognitive impairment associated with Alzheimer’s disease (AD). However, whether inhibition of PDE4 subtypes or their splice variants in the prefrontal cortex positively regulates synaptic plasticity and antioxidative stress,...

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Detalles Bibliográficos
Autores principales: Shi, Yongchuan, Lv, Jinpeng, Chen, Ling, Luo, Guojun, Tao, Mengjia, Pan, Jianchun, Hu, Xiaoxiong, Sheng, Jianwen, Zhang, Shanjin, Zhou, Min, Fan, Huizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446525/
https://www.ncbi.nlm.nih.gov/pubmed/34539384
http://dx.doi.org/10.3389/fnagi.2021.722580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446525/
https://www.ncbi.nlm.nih.gov/pubmed/34539384
http://dx.doi.org/10.3389/fnagi.2021.722580

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