Coiled-coil binding of the leucine zipper domains of APOL1 is necessary for the open cation channel conformation

Apolipoprotein L-I (APOL1) is a channel-forming effector of innate immunity. The common human APOL1 variant G0 provides protection against infection with certain Trypanosoma and Leishmania parasite species, but it cannot protect against the trypanosomes responsible for human African trypanosomiasis....

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Detalles Bibliográficos
Autores principales: Schaub, Charles, Lee, Penny, Racho-Jansen, Alisha, Giovinazzo, Joseph, Terra, Nada, Raper, Jayne, Thomson, Russell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446801/
https://www.ncbi.nlm.nih.gov/pubmed/34331942
http://dx.doi.org/10.1016/j.jbc.2021.101009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446801/
https://www.ncbi.nlm.nih.gov/pubmed/34331942
http://dx.doi.org/10.1016/j.jbc.2021.101009

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