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Coiled-coil binding of the leucine zipper domains of APOL1 is necessary for the open cation channel conformation
Apolipoprotein L-I (APOL1) is a channel-forming effector of innate immunity. The common human APOL1 variant G0 provides protection against infection with certain Trypanosoma and Leishmania parasite species, but it cannot protect against the trypanosomes responsible for human African trypanosomiasis....
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446801/ https://www.ncbi.nlm.nih.gov/pubmed/34331942 http://dx.doi.org/10.1016/j.jbc.2021.101009 |