USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates

The stability of a protein is regulated by a balance between its ubiquitylation and deubiquitylation. S-phase kinase-associated protein 2 (SKP2) is an oncogenic F-box protein that recognizes tumor suppressor substrates for targeted ubiquitylation by the E3 ligase SKP1-Cullin1-F-box and degradation b...

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Detalles Bibliográficos
Autores principales: Zhang, Fengwu, Zhao, Yongchao, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446802/
https://www.ncbi.nlm.nih.gov/pubmed/34425107
http://dx.doi.org/10.1016/j.jbc.2021.101109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446802/
https://www.ncbi.nlm.nih.gov/pubmed/34425107
http://dx.doi.org/10.1016/j.jbc.2021.101109

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