Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2

Actinins are strain-sensing actin cross-linkers that are ubiquitously expressed and harbor mutations in human diseases. We utilize CRISPR, pluripotent stem cells, and BioID to study actinin interactomes in human cardiomyocytes. We identify 324 actinin proximity partners, including those that are dep...

Descripción completa

Detalles Bibliográficos
Autores principales: Ladha, Feria A., Thakar, Ketan, Pettinato, Anthony M., Legere, Nicholas, Ghahremani, Shahnaz, Cohn, Rachel, Romano, Robert, Meredith, Emily, Chen, Yu-Sheng, Hinson, J. Travis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447243/
https://www.ncbi.nlm.nih.gov/pubmed/34380038
http://dx.doi.org/10.1016/j.celrep.2021.109512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447243/
https://www.ncbi.nlm.nih.gov/pubmed/34380038
http://dx.doi.org/10.1016/j.celrep.2021.109512

Ejemplares similares