Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment

BACKGROUND: Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or SKQ1, would provide better protection against Dox than co-treatment. METHODS: We investigated the...

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Detalles Bibliográficos
Autores principales: Sacks, Brian, Onal, Halil, Martorana, Rose, Sehgal, Amogh, Harvey, Amanda, Wastella, Catherine, Ahmad, Hafsa, Ross, Erin, Pjetergjoka, Adona, Prasad, Sachin, Barsotti, Robert, Young, Lindon H., Chen, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447656/
https://www.ncbi.nlm.nih.gov/pubmed/34530934
http://dx.doi.org/10.1186/s40360-021-00518-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447656/
https://www.ncbi.nlm.nih.gov/pubmed/34530934
http://dx.doi.org/10.1186/s40360-021-00518-6

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