R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells

BACKGROUND: Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1). Neurofibromin loss potentially hyperactivates classic Ras (H-Ras, N-Ras, K-Ras), M-Ras, and R-Ras (R-Ras, R-Ras2/TC21) subfamily proteins. W...

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Detalles Bibliográficos
Autores principales: Weber, Shannon M., Brossier, Nicole M., Prechtl, Amanda, Barnes, Stephen, Wilson, Landon S., Brosius, Stephanie N., Longo, Jody Fromm, Carroll, Steven L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447793/
https://www.ncbi.nlm.nih.gov/pubmed/34530870
http://dx.doi.org/10.1186/s12964-021-00773-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447793/
https://www.ncbi.nlm.nih.gov/pubmed/34530870
http://dx.doi.org/10.1186/s12964-021-00773-4

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