E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy calculation studies

The pandemic of the COVID-19 disease caused by SARS-CoV-2 has led to more than 200 million infections and over 4 million deaths worldwide. The progress in the developments of effective vaccines and neutralizing antibody therapeutics brings hopes to eliminate the threat of COVID-19. However, SARS-CoV...

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Detalles Bibliográficos
Autores principales: Wang, Wei Bu, Liang, Yu, Jin, Yu Qin, Zhang, Jing, Su, Ji Guo, Li, Qi Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447841/
https://www.ncbi.nlm.nih.gov/pubmed/34562851
http://dx.doi.org/10.1016/j.jmgm.2021.108035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447841/
https://www.ncbi.nlm.nih.gov/pubmed/34562851
http://dx.doi.org/10.1016/j.jmgm.2021.108035

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