Host Bioenergetic Parameters Reveal Cytotoxicity of Antituberculosis Drugs Undetected Using Conventional Viability Assays

High attrition rates in tuberculosis (TB) drug development have been largely attributed to safety, which is likely due to the use of endpoint assays measuring cell viability to detect drug cytotoxicity. In drug development for cancer, metabolic, and neurological disorders and for antibiotics, cytoto...

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Detalles Bibliográficos
Autores principales: Cumming, Bridgette M., Baig, Zainab, Addicott, Kelvin W., Chen, Dongquan, Steyn, Adrie J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448146/
https://www.ncbi.nlm.nih.gov/pubmed/34339269
http://dx.doi.org/10.1128/AAC.00932-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448146/
https://www.ncbi.nlm.nih.gov/pubmed/34339269
http://dx.doi.org/10.1128/AAC.00932-21

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