A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation

Gene variant discovery is becoming routine, but it remains difficult to usefully interpret the functional consequence or disease relevance of most variants. To fill this interpretation gap, experimental assays of variant function are becoming common place. Yet, it remains challenging to make these a...

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Detalles Bibliográficos
Autores principales: Ganguly, Payel, Madonsela, Landiso, Chao, Jesse T., Loewen, Christopher J. R., O’Connor, Timothy P., Verheyen, Esther M., Allan, Douglas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448351/
https://www.ncbi.nlm.nih.gov/pubmed/34492006
http://dx.doi.org/10.1371/journal.pgen.1009774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448351/
https://www.ncbi.nlm.nih.gov/pubmed/34492006
http://dx.doi.org/10.1371/journal.pgen.1009774

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