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A novel assay based on pre-equilibrium titration curves for the determination of enzyme inhibitor binding kinetics
Selection of pharmacological agents based on potency measurements performed at equilibrium fail to incorporate the kinetic aspects of the drug–target interaction. Here we describe a method for screening or characterization of enzyme inhibitors that allows the concomitant determination of the equilib...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448677/ https://www.ncbi.nlm.nih.gov/pubmed/34159406 http://dx.doi.org/10.1007/s00249-021-01554-0 |