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K(D) determination from time-resolved experiments on live cells with LigandTracer and reconciliation with end-point flow cytometry measurements
Design of next-generation therapeutics comes with new challenges and emulates technology and methods to meet them. Characterizing the binding of either natural ligands or therapeutic proteins to cell-surface receptors, for which relevant recombinant versions may not exist, represents one of these ch...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448686/ https://www.ncbi.nlm.nih.gov/pubmed/34302187 http://dx.doi.org/10.1007/s00249-021-01560-2 |