Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion

Dopaminergic (DA) cell death in Parkinson’s disease (PD) is associated with the gradual appearance of neuronal protein aggregates termed Lewy bodies (LBs) that are comprised of vesicular membrane structures and dysmorphic organelles in conjunction with the protein alpha-Synuclein (α-Syn). Although t...

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Detalles Bibliográficos
Autores principales: Tang, Qilin, Gao, Pan, Arzberger, Thomas, Höllerhage, Matthias, Herms, Jochen, Höglinger, Günter, Koeglsperger, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448865/
https://www.ncbi.nlm.nih.gov/pubmed/34535638
http://dx.doi.org/10.1038/s41419-021-04138-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448865/
https://www.ncbi.nlm.nih.gov/pubmed/34535638
http://dx.doi.org/10.1038/s41419-021-04138-0

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