Valproate activates the Snf1 kinase in Saccharomyces cerevisiae by decreasing the cytosolic pH

Valproate (VPA) is a widely used mood stabilizer, but its therapeutic mechanism of action is not understood. This knowledge gap hinders the development of more effective drugs with fewer side effects. Using the yeast model to elucidate the effects of VPA on cellular metabolism, we determined that th...

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Detalles Bibliográficos
Autores principales: Salsaa, Michael, Aziz, Kerestin, Lazcano, Pablo, Schmidtke, Michael W., Tarsio, Maureen, Hüttemann, Maik, Reynolds, Christian A., Kane, Patricia M., Greenberg, Miriam L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449051/
https://www.ncbi.nlm.nih.gov/pubmed/34428448
http://dx.doi.org/10.1016/j.jbc.2021.101110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449051/
https://www.ncbi.nlm.nih.gov/pubmed/34428448
http://dx.doi.org/10.1016/j.jbc.2021.101110

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