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Valproate activates the Snf1 kinase in Saccharomyces cerevisiae by decreasing the cytosolic pH
Valproate (VPA) is a widely used mood stabilizer, but its therapeutic mechanism of action is not understood. This knowledge gap hinders the development of more effective drugs with fewer side effects. Using the yeast model to elucidate the effects of VPA on cellular metabolism, we determined that th...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449051/ https://www.ncbi.nlm.nih.gov/pubmed/34428448 http://dx.doi.org/10.1016/j.jbc.2021.101110 |