Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage

OBJECTIVE: Murine-specific muricholic acids (MCAs) are reported to protect against obesity and associated metabolic disorders. However, the response of mice with genetic depletion of MCA to an obesogenic diet has not been evaluated. We used Cyp2c-deficient (Cyp2c(−/−)) mice, which lack MCAs and thus...

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Detalles Bibliográficos
Autores principales: Oteng, Antwi-Boasiako, Higuchi, Sei, Banks, Alexander S., Haeusler, Rebecca A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449133/
https://www.ncbi.nlm.nih.gov/pubmed/34438105
http://dx.doi.org/10.1016/j.molmet.2021.101326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449133/
https://www.ncbi.nlm.nih.gov/pubmed/34438105
http://dx.doi.org/10.1016/j.molmet.2021.101326

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