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Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SREBP1

COVID-19, caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has presented a serious risk to global public health. The viral main protease M(pro) (also called 3Cl(pro)) encoded by NSP5 is an enzyme essential for viral replication. However, very few host proteins have been experimentally...

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Detalles Bibliográficos
Autores principales: Zhang, Shilei, Wang, Jingfeng, Cheng, Genhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449311/
https://www.ncbi.nlm.nih.gov/pubmed/34452991
http://dx.doi.org/10.1073/pnas.2107108118